College of Agriculture & Natural Resources Reproductive and Developmental Sciences Training Program

College of Engineering

Biochemistry and Molecular Biology

Biography

Education/Degree
B.S. Columbia University, NY
M.S. University of Pennsylvania, PA
Ph.D. University of Pennsylvania, PA

Our laboratory is focused on understanding the signaling and regulatory mechanisms that are altered in diseases, such as obesity, Alzheimer’s disease and cancer. My group develops and applies metabolic engineering, bioinformatics, and systems biology approaches in combination with biochemical, biophysical, and molecular biology measurements and animal studies to identify targets and disease biomarkers. We are also developing polymeric-based drug delivery and tissue engineering platforms to modulate these pathways for treating these diseases.

Research Interests

Role of ER stress in diseases (cancer and AD)
Protein-lipid interactions
Use of crispr to reduce stem cell heterogeneity
Regenerative medicine and tissue engineering
Metabolic Engineering and Systems Biology

Recent Publications

1. Vocelle, D., Chan, C., and Walton, S. P., “Endocytosis controls sirna efficiency: implications for sirna therapeutic design and cell specific targeting” (2020) Nucleic Acid Therapeutics, 30(1): 22-32.
2. Whitehead, T. A., et al. “The Importance and Future of Biochemical Engineering”, (2020) Biotechnology and Bioengineering, 117(8), 2305-2318.
3. Vocelle, D., Chesniak, O., Smith, M. R., Chan, C., and Walton, S. P., “Kinetic analysis of the intracellular processing of sirnas by confocal microscopy”, (2020) Microscopy, 69(6), 401-407.
4. Nath, A., Oak, A., Chen, K., Li, I., Splichal, C., Portis, J., Foster, S., Walton, S. P., and Chan, C., “Palmitate-induced IRE1-XBP1-ZEB signaling represses desmoplakin expression and promotes cancer cell migration”, (2021) Molecular Cancer Research, 19(2), 240-248.
5. Splichal, R. C., Gredell, J. A., Vogel, E. B., Malefyt, A., Comiskey, G., Smith, M. R., Chan, C., and Wlaton, S. P., “Modulating Polymer-siRNA Binding Does Not Promote Polyplex-Mediated Silencing”, (2021) Nucleic Acid Therapeutics (special issue “Delivery of Antisense RNA Therapeutics: Turning Negative Results into a Positive Development”), Published Online July 29, 2020, 31(3), 229-236.
6. Chan, C., Foster, S. T., Chan, K. G., Cacace, M. J., Ladd, S. L., Sandum, C. T., Wright, P. T., and Wright, N. T., “Repositioned drugs for COVID-19 – impact on multiple organs”, (2021) SN Comprehensive Clinical Medicine, 21, 1-18.
7. Lawson, H. D., Walton, S. P., and Chan, C., “Metal−Organic Frameworks for Drug Delivery: A Design Perspective”, (2021) ACS Applied Materials & Interfaces, 13(6): 7004–7020.
8. Thompson, R., Mazur, N., Yang, J., and Chan, C., "Soft Substrates Induce Neural Differentiation via the Neuron Restrictive Silencer Factor", (2022) Biochemical Engineering Journal, 189: 108724.
9. Wright, N. T., Fu, B., Chan, C., and Ladd, S., "Modeling Transport of Soluble Proteins and Metabolites in the Brain” in Modelling of Mass Transport Processes in Biological Media, Sid Becker and Filippo De Monte, Eds., Elsevier, 2022, Chapter 16:493-508.
10. Aleksandra Kostina; Yonatan R. Lewis-Israeli; Mishref Abdelhamid; Mitchell A. Gabalski; Artem Kiselev, Brett D. Volmert; Haley Lankerd; Amanda R. Huang; Aaron H. Wasserman; Todd Lydic; Christina Chan; Isoken Olomu; Aitor Aguirre, “ER stress and lipid imbalance drive embryonic cardiomyopathy in a human heart organoid model of pregestational diabetes”, (2023) Cell Stem Cell, 19: 317-330.
11. Splichal, R. C., Chen, K., Walton, S. P., and Chan, C., “The Role of Endoplasmic Reticulum Stress and on Reducing Recombinant Protein Expression in Eukaryotic Cells”, (2024) (in press).
    
    

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